Breastfeeding as a protective factor against the development of childhood acute lymphoblastic leukemia
DOI:
https://doi.org/10.35622/j.ram.2023.01.005Keywords:
breastfeeding, childhood cancer, acute lymphocytic leukemia, childAbstract
The aim of this study is to determine whether breastfeeding acts as a protective factor against the development of childhood acute lymphoblastic leukemia. We conducted a systematic review of articles published between 2012 and 2022 that investigated the association between breastfeeding and acute lymphoblastic leukemia in PubMed, Google Scholar, Scopus and SciELO. A total of 128 papers were identified in the initial search. Finally, 5 articles of case-control design were selected. The results indicate that human milk can reduce the risk of acute lymphoblastic leukemia in children by 44% (OR: 0.56, 95% CI: 0.35 - 0.90, p = 0.017). Children who were breastfed until 7-9 months have a lower risk of developing childhood leukemia (OR: 0.498, 95% CI: 0.318 - 0.780, p = 0.002). In conclusion, breastfeeding exerts a protective effect against the development of childhood acute lymphoblastic leukemia. Breastfeeding for a period of 6 months or longer decreases the risk of developing acute lymphoblastic leukemia.
Keyword: breastfeeding, childhood cancer, acute lymphocytic leukemia, child
References
Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, et al. International incidence of childhood cancer, 2001–10: a population-based registry study. The Lancet Oncology. 2017;18(6): 719–731. https://doi.org/10.1016/S1470-2045(17)30186-9.
González-Casagua MS, Bermeo-Calderón JD, Laverde-Gaona LA, Tafurt-Cardona Y. Carcinógenos ambientales asociados a cáncer infantil. Universidad y Salud. 2019;21(3): 270–276. https://doi.org/10.22267/rus.192103.164.
Jiménez-Morales S, Hidalgo-Miranda A, Ramírez-Bello J. Leucemia linfoblástica aguda infantil: una aproximación genómica. Boletín Médico del Hospital Infantil de México. 2017;74(1): 13–26. https://doi.org/10.1016/j.bmhimx.2016.07.007.
Brisson GD, Alves LR, Pombo-de-Oliveira MS. Genetic susceptibility in childhood acute leukaemias: a systematic review. ecancermedicalscience. 2015;9. https://doi.org/10.3332/ecancer.2015.539.
Saravia-Bartra MM, Cazorla P, Ignacio-Cconchoy FL, Cazorla-Saravia P. Lactancia materna exclusiva como factor protector de la leucemia linfoblástica aguda. Andes Pediatrica. 2021;92(1): 34. https://doi.org/10.32641/andespediatr.v92i1.2617.
Su Q, Sun X, Zhu L, Yan Q, Zheng P, Mao Y, et al. Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis. BMC Medicine. 2021;19(1): 90. https://doi.org/10.1186/s12916-021-01950-5.
Michie C. Breast feeding could reduce the risk of childhood leukaemias. Evidence Based Nursing. 2016;19(3): 83.1-83. https://doi.org/10.1136/eb-2015-102200.
Comité de Lactancia Materna de la Asociación Española de Pediatría. Lactancia materna en niños mayores o prolongada. [Internet]. Madrid: AEP;. 2017 [citado 23 de octubre de 2022]; Disponible en: https://www.aeped.es/comite-nutricion-y-lactancia-materna/lactancia-materna/documentos/lactancia-materna-en-ninos-mayores-o
Mezei G, Sudan M, Izraeli S, Kheifets L. Epidemiology of childhood leukemia in the presence and absence of Down syndrome. Cancer Epidemiology. 2014;38(5): 479–489. https://doi.org/10.1016/j.canep.2014.07.006.
Shu XO, Linet MS, Steinbuch M, Wen WQ, Buckley JD, Neglia JP, et al. Breast-Feeding and Risk of Childhood Acute Leukemia. JNCI Journal of the National Cancer Institute. 1999;91(20): 1765–1772. https://doi.org/10.1093/jnci/91.20.1765.
Altinkaynak S, Selimoglu MA, Turgut A, Kilicaslan B, Ertekin V. Breast-feeding Duration and Childhood Acute Leukemia and Lymphomas in a Sample of Turkish Children: Journal of Pediatric Gastroenterology and Nutrition. 2006;42(5): 568–572. https://doi.org/10.1097/01.mpg.0000215309.93911.84.
Kwan ML, Buffler PA, Wiemels JL, Metayer C, Selvin S, Ducore JM, et al. Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia. British Journal of Cancer. 2005;93(3): 379–384. https://doi.org/10.1038/sj.bjc.6602706.
Gao Z, Wang R, Qin ZX, Dong A, Liu CB. Protective effect of breastfeeding against childhood leukemia in Zhejiang Province, P. R. China: a retrospective case-control study. Libyan Journal of Medicine. 2019;14(1): 1508273. https://doi.org/10.1080/19932820.2018.1508273.
Lingappa AL, Kalapalar SR, Rudrappa SR, Manjunatha S. Breastfeeding and Its Associated Risk in Children with Acute Leukemia: A Retrospective Study. Indian Journal of Medical and Paediatric Oncology. 2018;39(03): 312–315. https://doi.org/10.4103/ijmpo.ijmpo_18_17.
Greenop KR, Bailey HD, Miller M, Scott RJ, Attia J, Ashton LJ, et al. Breastfeeding and Nutrition to 2 Years of Age and Risk of Childhood Acute Lymphoblastic Leukemia and Brain Tumors. Nutrition and Cancer. 2015;67(3): 431–441. https://doi.org/10.1080/01635581.2015.998839.
Karimi M, Haghighat M, Dialameh Z, Tahmasbi L, Parand S, Bardestani M. Breastfeeding as a Protective Effect Against Childhood Leukemia and Lymphoma. Iranian Red Crescent Medical Journal. 2016;18(9). https://doi.org/10.5812/ircmj.29771.
Eden T. Aetiology of childhood leukaemia. Cancer Treatment Reviews. 2010;36(4): 286–297. https://doi.org/10.1016/j.ctrv.2010.02.004.
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, et al. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives. 2022;130(8): 087001. https://doi.org/10.1289/EHP11092.
Navabi A, Aznab M, Heydarpour F. The association between microRNA polymorphisms and the risk of childhood acute lymphoblastic leukemia: A meta-analysis. Cancer Epidemiology. 2022;81: 102285. https://doi.org/10.1016/j.canep.2022.102285.
Nguyen A, Crespi CM, Vergara X, Kheifets L. Commercial outdoor plant nurseries as a confounder for electromagnetic fields and childhood leukemia risk. Environmental Research. 2022;212: 113446. https://doi.org/10.1016/j.envres.2022.113446.
Bamouni S, Hémon D, Faure L, Clavel J, Goujon S. Residential proximity to croplands at birth and childhood leukaemia. Environmental Health. 2022;21(1): 103. https://doi.org/10.1186/s12940-022-00909-0.
Kim KU, Kim WH, Jeong CH, Yi DY, Min H. More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer. International Journal of Molecular Sciences. 2020;21(19): 7327. https://doi.org/10.3390/ijms21197327.
Ballard O, Morrow AL. Human Milk Composition. Pediatric Clinics of North America. 2013;60(1): 49–74. https://doi.org/10.1016/j.pcl.2012.10.002.
Kim MH, Shim KS, Yi DY, Lim IS, Chae SA, Yun SW, et al. Macronutrient Analysis of Human Milk according to Storage and Processing in Korean Mother. Pediatric Gastroenterology, Hepatology & Nutrition. 2019;22(3): 262. https://doi.org/10.5223/pghn.2019.22.3.262.
Schraw JM, Dong YQ, Okcu MF, Scheurer ME, Forman MR. Do longer formula feeding and later introduction of solids increase risk for pediatric acute lymphoblastic leukemia? Cancer Causes & Control. 2014;25(1): 73–80. https://doi.org/10.1007/s10552-013-0309-7.
Bernard JY, De Agostini M, Forhan A, Alfaiate T, Bonet M, Champion V, et al. Breastfeeding Duration and Cognitive Development at 2 and 3 Years of Age in the EDEN Mother–Child Cohort. The Journal of Pediatrics. 2013;163(1): 36-42.e1. https://doi.org/10.1016/j.jpeds.2012.11.090.
Amitay EL, Keinan-Boker L. Breastfeeding and Childhood Leukemia Incidence: A Meta-analysis and Systematic Review. JAMA Pediatrics. 2015;169(6): e151025. https://doi.org/10.1001/jamapediatrics.2015.1025.
Gómez-Gutiérrez M. Valoración de la lactancia materna prolongada en madres con formación sanitaria frente a madres sin formación sanitaria. Nure Inv. 2021;18(112): 1–9. Disponible en: https://www.nureinvestigacion.es/OJS/index.php/nure/article/view/2101/966.
Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics. 2005;115(2): 496–506. https://doi.org/10.1542/peds.2004-2491.
Gong QQ, Quan DD, Guo C, Zhang C, Zhang ZJ. Association between maternal breastfeeding and risk of systemic neoplasms of offspring. Italian Journal of Pediatrics. 2022;48(1): 98. https://doi.org/10.1186/s13052-022-01292-9.
Rudant J, Lightfoot T, Urayama KY, Petridou E, Dockerty JD, Magnani C, et al. Childhood Acute Lymphoblastic Leukemia and Indicators of Early Immune Stimulation: A Childhood Leukemia International Consortium Study. American Journal of Epidemiology. 2015;181(8): 549–562. https://doi.org/10.1093/aje/kwu298.
Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, et al. Infant milk-feeding practices and childhood leukemia: a systematic review. Am J Clin Nutr. 2019;109(Supplement_1): 757S-771S. https://doi.org/10.1093/ajcn/nqy306.
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Copyright (c) 2022 Kevin Minchola Castañeda, Fátima Morales-Ibañez, Angie Montalvo-Rodríguez, José Moncada-Carrera
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